Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration
Identifieur interne : 002530 ( Main/Exploration ); précédent : 002529; suivant : 002531Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration
Auteurs : Colleen L. Lau [Australie] ; Kimberly Y. Won [États-Unis] ; Luke Becker [Australie] ; Ricardo J. Soares Magalhaes [Australie] ; Saipale Fuimaono ; Wayne Melrose [Australie] ; Patrick J. Lammie [États-Unis] ; Patricia M. Graves [Australie]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de regroupements, Analyse spatiale, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Enquêtes et questionnaires, Femelle, Filariose lymphatique (), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Jeune adulte, Mâle, Risque, Samoa américaines (épidémiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Wuchereria bancrofti (immunologie), Études séroépidémiologiques.
- MESH :
- immunologie : Wuchereria bancrofti.
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Samoa américaines.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de regroupements, Analyse spatiale, Animaux, Enquêtes et questionnaires, Femelle, Filariose lymphatique, Humains, Jeune adulte, Mâle, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, American Samoa (epidemiology), Animals, Antibodies, Helminth (blood), Antigens, Helminth (blood), Cluster Analysis, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Female, Humans, Male, Middle Aged, Risk, Seroepidemiologic Studies, Spatial Analysis, Surveys and Questionnaires, Wuchereria bancrofti (immunology), Young Adult.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- geographic , epidemiology : American Samoa.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Cluster Analysis, Female, Humans, Male, Middle Aged, Risk, Seroepidemiologic Studies, Spatial Analysis, Surveys and Questionnaires, Young Adult.
Abstract
As part of the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted mass drug administration (MDA) from 2000–2006, and passed transmission assessment surveys in 2011–2012. We examined the seroprevalence and spatial epidemiology of LF post-MDA to inform strategies for ongoing surveillance and to reduce resurgence risk.
ELISA for LF antigen (Og4C3) and antibodies (Wb123, Bm14) were performed on a geo-referenced serum bank of 807 adults collected in 2010. Risk factors assessed for association with sero-positivity included age, sex, years lived in American Samoa, and occupation. Geographic clustering of serological indicators was investigated to identify spatial dependence and household-level clustering.
Og4C3 antigen of >128 units (positive) were found in 0.75% (95% CI 0.3–1.6%) of participants, and >32 units (equivocal plus positive) in 3.2% (95% CI 0.6–4.7%). Seroprevalence of Wb123 and Bm14 antibodies were 8.1% (95% CI 6.3–10.2%) and 17.9% (95% CI 15.3–20.7%) respectively. Antigen-positive individuals were identified in all ages, and antibody prevalence higher in older ages. Prevalence was higher in males, and inversely associated with years lived in American Samoa. Spatial distribution of individuals varied significantly with positive and equivocal levels of Og4C3 antigen, but not with antibodies. Using Og4C3 cutoff points of >128 units and >32 units, average cluster sizes were 1,242 m and 1,498 m, and geographical proximity of households explained 85% and 62% of the spatial variation respectively.
High-risk populations for LF in American Samoa include adult males and recent migrants. We identified locations and estimated the size of possible residual foci of antigen-positive adults, demonstrating the value of spatial analysis in post-MDA surveillance. Strategies to monitor cluster residents and high-risk groups are needed to reduce resurgence risk. Further research is required to quantify factors contributing to LF transmission at the last stages of elimination to ensure that programme achievements are sustained.
Url:
DOI: 10.1371/journal.pntd.0003297
PubMed: 25393716
PubMed Central: 4230933
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000414
- to stream Pmc, to step Curation: 000414
- to stream Pmc, to step Checkpoint: 001784
- to stream PubMed, to step Corpus: 001213
- to stream PubMed, to step Curation: 001213
- to stream PubMed, to step Checkpoint: 001213
- to stream Ncbi, to step Merge: 006D03
- to stream Ncbi, to step Curation: 006D03
- to stream Ncbi, to step Checkpoint: 006D03
- to stream Main, to step Merge: 002533
- to stream Main, to step Curation: 002530
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration</title>
<author><name sortKey="Lau, Colleen L" sort="Lau, Colleen L" uniqKey="Lau C" first="Colleen L." last="Lau">Colleen L. Lau</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Research School of Population Health, Australian National University, Canberra, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research School of Population Health, Australian National University, Canberra</wicri:regionArea>
<wicri:noRegion>Canberra</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Luke" sort="Becker, Luke" uniqKey="Becker L" first="Luke" last="Becker">Luke Becker</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soares Magalhaes, Ricardo J" sort="Soares Magalhaes, Ricardo J" uniqKey="Soares Magalhaes R" first="Ricardo J." last="Soares Magalhaes">Ricardo J. Soares Magalhaes</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>School of Veterinary Science, The University of Queensland, Gatton, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Veterinary Science, The University of Queensland, Gatton</wicri:regionArea>
<wicri:noRegion>Gatton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fuimaono, Saipale" sort="Fuimaono, Saipale" uniqKey="Fuimaono S" first="Saipale" last="Fuimaono">Saipale Fuimaono</name>
<affiliation><nlm:aff id="aff6"><addr-line>American Samoa Department of Health, Pago Pago, American Samoa</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">American Samoa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Graves, Patricia M" sort="Graves, Patricia M" uniqKey="Graves P" first="Patricia M." last="Graves">Patricia M. Graves</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25393716</idno>
<idno type="pmc">4230933</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230933</idno>
<idno type="RBID">PMC:4230933</idno>
<idno type="doi">10.1371/journal.pntd.0003297</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000414</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000414</idno>
<idno type="wicri:Area/Pmc/Curation">000414</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000414</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001784</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001784</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001213</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001213</idno>
<idno type="wicri:Area/PubMed/Curation">001213</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001213</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001213</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001213</idno>
<idno type="wicri:Area/Ncbi/Merge">006D03</idno>
<idno type="wicri:Area/Ncbi/Curation">006D03</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">006D03</idno>
<idno type="wicri:doubleKey">1935-2727:2014:Lau C:seroprevalence:and:spatial</idno>
<idno type="wicri:Area/Main/Merge">002533</idno>
<idno type="wicri:Area/Main/Curation">002530</idno>
<idno type="wicri:Area/Main/Exploration">002530</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration</title>
<author><name sortKey="Lau, Colleen L" sort="Lau, Colleen L" uniqKey="Lau C" first="Colleen L." last="Lau">Colleen L. Lau</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Research School of Population Health, Australian National University, Canberra, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research School of Population Health, Australian National University, Canberra</wicri:regionArea>
<wicri:noRegion>Canberra</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Luke" sort="Becker, Luke" uniqKey="Becker L" first="Luke" last="Becker">Luke Becker</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soares Magalhaes, Ricardo J" sort="Soares Magalhaes, Ricardo J" uniqKey="Soares Magalhaes R" first="Ricardo J." last="Soares Magalhaes">Ricardo J. Soares Magalhaes</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Children's Health and Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>School of Veterinary Science, The University of Queensland, Gatton, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Veterinary Science, The University of Queensland, Gatton</wicri:regionArea>
<wicri:noRegion>Gatton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fuimaono, Saipale" sort="Fuimaono, Saipale" uniqKey="Fuimaono S" first="Saipale" last="Fuimaono">Saipale Fuimaono</name>
<affiliation><nlm:aff id="aff6"><addr-line>American Samoa Department of Health, Pago Pago, American Samoa</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">American Samoa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Graves, Patricia M" sort="Graves, Patricia M" uniqKey="Graves P" first="Patricia M." last="Graves">Patricia M. Graves</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>WHO Collaborating Centre for Lymphatic Filariasis, Soil-Transmitted Helminths, and other Neglected Tropical Diseases, Division of Tropical Health and Medicine, James Cook University, Cairns</wicri:regionArea>
<wicri:noRegion>Cairns</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Neglected Tropical Diseases</title>
<idno type="ISSN">1935-2727</idno>
<idno type="eISSN">1935-2735</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>American Samoa (epidemiology)</term>
<term>Animals</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth (blood)</term>
<term>Cluster Analysis</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Elephantiasis, Filarial (prevention & control)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk</term>
<term>Seroepidemiologic Studies</term>
<term>Spatial Analysis</term>
<term>Surveys and Questionnaires</term>
<term>Wuchereria bancrofti (immunology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de regroupements</term>
<term>Analyse spatiale</term>
<term>Animaux</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe (sang)</term>
<term>Enquêtes et questionnaires</term>
<term>Femelle</term>
<term>Filariose lymphatique ()</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Filariose lymphatique (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Risque</term>
<term>Samoa américaines (épidémiologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Études séroépidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term>
<term>Antigens, Helminth</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>American Samoa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term>
<term>Antigènes d'helminthe</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Samoa américaines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Cluster Analysis</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk</term>
<term>Seroepidemiologic Studies</term>
<term>Spatial Analysis</term>
<term>Surveys and Questionnaires</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de regroupements</term>
<term>Analyse spatiale</term>
<term>Animaux</term>
<term>Enquêtes et questionnaires</term>
<term>Femelle</term>
<term>Filariose lymphatique</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études séroépidémiologiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>As part of the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted mass drug administration (MDA) from 2000–2006, and passed transmission assessment surveys in 2011–2012. We examined the seroprevalence and spatial epidemiology of LF post-MDA to inform strategies for ongoing surveillance and to reduce resurgence risk.</p>
</sec>
<sec><title>Methods</title>
<p>ELISA for LF antigen (Og4C3) and antibodies (Wb123, Bm14) were performed on a geo-referenced serum bank of 807 adults collected in 2010. Risk factors assessed for association with sero-positivity included age, sex, years lived in American Samoa, and occupation. Geographic clustering of serological indicators was investigated to identify spatial dependence and household-level clustering.</p>
</sec>
<sec><title>Results</title>
<p>Og4C3 antigen of >128 units (positive) were found in 0.75% (95% CI 0.3–1.6%) of participants, and >32 units (equivocal plus positive) in 3.2% (95% CI 0.6–4.7%). Seroprevalence of Wb123 and Bm14 antibodies were 8.1% (95% CI 6.3–10.2%) and 17.9% (95% CI 15.3–20.7%) respectively. Antigen-positive individuals were identified in all ages, and antibody prevalence higher in older ages. Prevalence was higher in males, and inversely associated with years lived in American Samoa. Spatial distribution of individuals varied significantly with positive and equivocal levels of Og4C3 antigen, but not with antibodies. Using Og4C3 cutoff points of >128 units and >32 units, average cluster sizes were 1,242 m and 1,498 m, and geographical proximity of households explained 85% and 62% of the spatial variation respectively.</p>
</sec>
<sec><title>Conclusions</title>
<p>High-risk populations for LF in American Samoa include adult males and recent migrants. We identified locations and estimated the size of possible residual foci of antigen-positive adults, demonstrating the value of spatial analysis in post-MDA surveillance. Strategies to monitor cluster residents and high-risk groups are needed to reduce resurgence risk. Further research is required to quantify factors contributing to LF transmission at the last stages of elimination to ensure that programme achievements are sustained.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ichimori, K" uniqKey="Ichimori K">K Ichimori</name>
</author>
<author><name sortKey="Crump, A" uniqKey="Crump A">A Crump</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ciferri, F" uniqKey="Ciferri F">F Ciferri</name>
</author>
<author><name sortKey="Siliga, N" uniqKey="Siliga N">N Siliga</name>
</author>
<author><name sortKey="Long, G" uniqKey="Long G">G Long</name>
</author>
<author><name sortKey="Kessel, Jf" uniqKey="Kessel J">JF Kessel</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ichimori, K" uniqKey="Ichimori K">K Ichimori</name>
</author>
<author><name sortKey="Tupuimalagi Toelupe, P" uniqKey="Tupuimalagi Toelupe P">P Tupuimalagi-Toelupe</name>
</author>
<author><name sortKey="Iosia, Vt" uniqKey="Iosia V">VT Iosia</name>
</author>
<author><name sortKey="Graves, Pm" uniqKey="Graves P">PM Graves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huppatz, C" uniqKey="Huppatz C">C Huppatz</name>
</author>
<author><name sortKey="Durrheim, D" uniqKey="Durrheim D">D Durrheim</name>
</author>
<author><name sortKey="Lammie, P" uniqKey="Lammie P">P Lammie</name>
</author>
<author><name sortKey="Kelly, P" uniqKey="Kelly P">P Kelly</name>
</author>
<author><name sortKey="Melrose, W" uniqKey="Melrose W">W Melrose</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mladonicky, Jm" uniqKey="Mladonicky J">JM Mladonicky</name>
</author>
<author><name sortKey="King, Jd" uniqKey="King J">JD King</name>
</author>
<author><name sortKey="Liang, Jl" uniqKey="Liang J">JL Liang</name>
</author>
<author><name sortKey="Chambers, E" uniqKey="Chambers E">E Chambers</name>
</author>
<author><name sortKey="Pa Au, M" uniqKey="Pa Au M">M Pa'au</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, Bk" uniqKey="Chu B">BK Chu</name>
</author>
<author><name sortKey="Deming, M" uniqKey="Deming M">M Deming</name>
</author>
<author><name sortKey="Biritwum, Nk" uniqKey="Biritwum N">NK Biritwum</name>
</author>
<author><name sortKey="Bougma, Wr" uniqKey="Bougma W">WR Bougma</name>
</author>
<author><name sortKey="Dorkenoo, Am" uniqKey="Dorkenoo A">AM Dorkenoo</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="King, Jd" uniqKey="King J">JD King</name>
</author>
<author><name sortKey="Zielinski Gutierrez, E" uniqKey="Zielinski Gutierrez E">E Zielinski-Gutierrez</name>
</author>
<author><name sortKey="Pa Au, M" uniqKey="Pa Au M">M Pa'au</name>
</author>
<author><name sortKey="Lammie, P" uniqKey="Lammie P">P Lammie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chambers, Ew" uniqKey="Chambers E">EW Chambers</name>
</author>
<author><name sortKey="Mcclintock, Sk" uniqKey="Mcclintock S">SK McClintock</name>
</author>
<author><name sortKey="Avery, Mf" uniqKey="Avery M">MF Avery</name>
</author>
<author><name sortKey="King, Jd" uniqKey="King J">JD King</name>
</author>
<author><name sortKey="Bradley, Mh" uniqKey="Bradley M">MH Bradley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burkot, Tr" uniqKey="Burkot T">TR Burkot</name>
</author>
<author><name sortKey="Durrheim, Dn" uniqKey="Durrheim D">DN Durrheim</name>
</author>
<author><name sortKey="Melrose, Wd" uniqKey="Melrose W">WD Melrose</name>
</author>
<author><name sortKey="Speare, R" uniqKey="Speare R">R Speare</name>
</author>
<author><name sortKey="Ichimori, K" uniqKey="Ichimori K">K Ichimori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramaiah, Kd" uniqKey="Ramaiah K">KD Ramaiah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joseph, H" uniqKey="Joseph H">H Joseph</name>
</author>
<author><name sortKey="Moloney, J" uniqKey="Moloney J">J Moloney</name>
</author>
<author><name sortKey="Maiava, F" uniqKey="Maiava F">F Maiava</name>
</author>
<author><name sortKey="Mcclintock, S" uniqKey="Mcclintock S">S McClintock</name>
</author>
<author><name sortKey="Lammie, P" uniqKey="Lammie P">P Lammie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drexler, N" uniqKey="Drexler N">N Drexler</name>
</author>
<author><name sortKey="Washington, Ch" uniqKey="Washington C">CH Washington</name>
</author>
<author><name sortKey="Lovegrove, M" uniqKey="Lovegrove M">M Lovegrove</name>
</author>
<author><name sortKey="Grady, C" uniqKey="Grady C">C Grady</name>
</author>
<author><name sortKey="Milord, Md" uniqKey="Milord M">MD Milord</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Cl" uniqKey="Lau C">CL Lau</name>
</author>
<author><name sortKey="Clements, Ac" uniqKey="Clements A">AC Clements</name>
</author>
<author><name sortKey="Skelly, C" uniqKey="Skelly C">C Skelly</name>
</author>
<author><name sortKey="Dobson, Aj" uniqKey="Dobson A">AJ Dobson</name>
</author>
<author><name sortKey="Smythe, Ld" uniqKey="Smythe L">LD Smythe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Cl" uniqKey="Lau C">CL Lau</name>
</author>
<author><name sortKey="Dobson, Aj" uniqKey="Dobson A">AJ Dobson</name>
</author>
<author><name sortKey="Smythe, Ld" uniqKey="Smythe L">LD Smythe</name>
</author>
<author><name sortKey="Fearnley, Ej" uniqKey="Fearnley E">EJ Fearnley</name>
</author>
<author><name sortKey="Skelly, C" uniqKey="Skelly C">C Skelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J Kubofcik</name>
</author>
<author><name sortKey="Fink, Dl" uniqKey="Fink D">DL Fink</name>
</author>
<author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gass, K" uniqKey="Gass K">K Gass</name>
</author>
<author><name sortKey="Beau De Rochars, Mv" uniqKey="Beau De Rochars M">MV Beau de Rochars</name>
</author>
<author><name sortKey="Boakye, D" uniqKey="Boakye D">D Boakye</name>
</author>
<author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name>
</author>
<author><name sortKey="Fischer, Pu" uniqKey="Fischer P">PU Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steel, C" uniqKey="Steel C">C Steel</name>
</author>
<author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J Kubofcik</name>
</author>
<author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name>
</author>
<author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, Jl" uniqKey="Liang J">JL Liang</name>
</author>
<author><name sortKey="King, Jd" uniqKey="King J">JD King</name>
</author>
<author><name sortKey="Ichimori, K" uniqKey="Ichimori K">K Ichimori</name>
</author>
<author><name sortKey="Handzel, T" uniqKey="Handzel T">T Handzel</name>
</author>
<author><name sortKey="Pa Au, M" uniqKey="Pa Au M">M Pa'au</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kelly, Gc" uniqKey="Kelly G">GC Kelly</name>
</author>
<author><name sortKey="Tanner, M" uniqKey="Tanner M">M Tanner</name>
</author>
<author><name sortKey="Vallely, A" uniqKey="Vallely A">A Vallely</name>
</author>
<author><name sortKey="Clements, A" uniqKey="Clements A">A Clements</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duncombe, J" uniqKey="Duncombe J">J Duncombe</name>
</author>
<author><name sortKey="Lau, C" uniqKey="Lau C">C Lau</name>
</author>
<author><name sortKey="Weinstein, P" uniqKey="Weinstein P">P Weinstein</name>
</author>
<author><name sortKey="Aaskov, J" uniqKey="Aaskov J">J Aaskov</name>
</author>
<author><name sortKey="Rourke, M" uniqKey="Rourke M">M Rourke</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><noCountry><name sortKey="Fuimaono, Saipale" sort="Fuimaono, Saipale" uniqKey="Fuimaono S" first="Saipale" last="Fuimaono">Saipale Fuimaono</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Lau, Colleen L" sort="Lau, Colleen L" uniqKey="Lau C" first="Colleen L." last="Lau">Colleen L. Lau</name>
</noRegion>
<name sortKey="Becker, Luke" sort="Becker, Luke" uniqKey="Becker L" first="Luke" last="Becker">Luke Becker</name>
<name sortKey="Graves, Patricia M" sort="Graves, Patricia M" uniqKey="Graves P" first="Patricia M." last="Graves">Patricia M. Graves</name>
<name sortKey="Lau, Colleen L" sort="Lau, Colleen L" uniqKey="Lau C" first="Colleen L." last="Lau">Colleen L. Lau</name>
<name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name>
<name sortKey="Soares Magalhaes, Ricardo J" sort="Soares Magalhaes, Ricardo J" uniqKey="Soares Magalhaes R" first="Ricardo J." last="Soares Magalhaes">Ricardo J. Soares Magalhaes</name>
<name sortKey="Soares Magalhaes, Ricardo J" sort="Soares Magalhaes, Ricardo J" uniqKey="Soares Magalhaes R" first="Ricardo J." last="Soares Magalhaes">Ricardo J. Soares Magalhaes</name>
</country>
<country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name>
</region>
<name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002530 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002530 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4230933 |texte= Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25393716" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |